Title: Domain Decomposition Algorithms for PDE problems with Large Scale Variations Authors: Luc Giraud and Ray Tuminaro Organization: CERFACS 42 Ave. Gustave Coriolis 31057 Toulouse Cedex France Phone: (33) 61 19 30 21 or (33) 61 19 30 25 fax: (33) 61 19 30 00 email: tuminaro@cerfacs.fr or giraud@cerfacs.fr We consider a Schur complement BPS-like domain decomposition algorithm for PDE problems whose coefficients vary greatly. In particular, we focus on two problems: anisotropic phenomena and large changes in the PDE coefficients as one moves spatial within the domain. We consider both Fourier and probe based interface preconditioners. However, our focus is primarily on probing as the large scale variations can make the Fourier techniques somewhat less efficient. To cope with anisotropic phenomena, we introduce additional band matrices (in the context of the probe preconditioner) to approximate the coupling between neighboring interfaces. To address coefficient variations over the domain, we make use of the close connection between domain decomposition and multigrid and introduce specialized interpolation, projection, and averaging techniques (as in multigrid methods) to develop an accurate coarse grid approximation. We demonstrate the benefits of the new approach using both analysis on model problems as well as computational experiments on difficult application problems such as the Drift-Diffusion equations arising from semiconductor modeling.